Eternals
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Although the MCU has yet to pay off Eternals' cliffhanger, Phase 2's Avengers: Age of Ultron revealed what it may mean for humanity a decade ago. The MCU's Earth has been threatened multiple times throughout the years, from Loki's failed invasion of Earth to Thanos' successful plan to wipe out half of all life in the universe. The Multiverse Saga keeps raising the stakes, with projects like Loki, Spider-Man: No Way Home, Doctor Strange in the Multiverse of Madness, and Ant-Man and the Wasp: Quantumania endangering the entirety of Earth-616 without human society even realizing it.