John Stamos has hilarious reaction to the NASA Artemis II crew's Full House spoof

Full House alum John Stamos had a hilarious reaction to 'Full Capsule,' the NASA Artemis II crew's spoof of the ABC sitcom.

All four astronauts - including commander Reid Wiseman - took part in the parody uploaded to NASA's social media accounts on Sunday, which featured each crew member grinning to the camera the way sitcoms do in the opening credits.

Pilot Victor Glover flashed a thumbs up while mission specialist #1 Christina Koch waved as her curly hair floated above her head in zero gravity.

Mission specialist #2 Jeremy Hansen busied himself with a nylon tarp, not looking at the camera, while Rise, a zero-gravity indicator designed by eight-year-old Lucas Ye of California smiling with its little baseball cap on.

'We were doing scenes from bad 80s sitcoms when they introduce the cast of characters,' Wiseman explained.

'So that's why we did all those. And we are cracking up, up here.'

In the Instagram comments section, the 62-year-old eighties heartthrob reacted: 'Bad 80s sitcoms? Honored!'

Stamos famously portrayed Uncle Jesse Katsopolis in Full House from 1987-1995 and its Netflix reboot Fuller House from 2016-2020.

'@johnstamos "Talk to me!" – What the Artemis II crew will say to the Moon tomorrow, probably,' NASA replied.

The honorary Beach Boy - who boasts 10.7 million social media followers - was so honored by the astronauts taking the time to be silly during their ten-day lunar flyby mission that he reposted the video.

Stamos captioned the wholesome clip: 'Honestly? If aliens make contact now, they're gonna think our entire civilization is just hugs, life lessons and Uncle Jesse fixing everything in 22 minutes. @nasa @nasaartemis.'

On Monday, Artemis II made history as the first mission to go further into space (252,756 miles) than any humans all within the confines of the 16.5ft x 10.8ft Orion capsule (roughly the interior size of two minivans).

This Friday, Orion will re-enter Earth's atmosphere at about 25,000 miles per hour (the fastest ever attempted) before splashing down in the Pacific Ocean near San Diego, CA where they US Navy will be waiting for recovery.

Last month, People revealed that the two-time Emmy-nominated producer will publish his second literary effort, a book on fatherhood, through Macmillan Publishers imprint Henry Holt & Co.

This Friday, Stamos and his second wife Caitlin McHugh will celebrate the eighth birthday of their son Billy.

The Cologuard brand ambassador is 23 years older than the half-Filipino beauty, but they're still going strong after eight years of marriage.

Stamos executive produced and stars in Raviv Ullman and Greg Yagolnitzer's comedy horror-thriller Drag, which screens this Friday at the Overlook Film Festival in New Orleans, LA.

The Danny DeVito-produced flick about robber sisters also stars his nepo baby Lucy DeVito, Lizzy Caplan and Christine Ko.

The Palm Royale guest star will also portray Chase Brylan in the second season of Netflix drama The Hunting Wives streaming later this year.