The MCU's Spider-Man franchise boasts a plethora of foes both from Earth-616 and beyond. However, there are still plenty of Spider-Man villains that have yet to make it to the big screen. Keeping that in mind, there are several good options for Spider-Man 4 starring Tom Holland as Peter Parker.
The MCU's recent "Home" trilogy recently concluded with 2021's Spider-Man: No Way Home, a multiversal adventure featuring not only villains from past Spider-Man franchises, but also its previous Peter Parkers (Tobey Maguire and Andrew Garfield). At the moment, it's currently unknown if the upcoming Spider-Man 4 will be another multiversal epic or more of a grounded feature as Spider-Man truly becomes a New York vigilante. Either way, here are 10 Marvel villains perfect for Spider-Man 4 who've never been depicted in live-action before.
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