Monk
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Bitty Schram left Monk during season 3, and the way the series handled Sharona’s exit arguably saved the show and made sure it would continue for five more seasons despite losing one of its best characters. Even though Sharona was only in three out of the eight seasons of Monk, she remained an integral part of the show’s legacy. The fact that Sharona’s absence was felt during Mr. Monk’s Last Case: A Monk Movie shows how important the character is to the world of Monk, which is why replacing her was such a difficult task.