Savannah Guthrie's Missing Mom’s Home Declared “Crime Scene”

“We know she didn't just walk out of there, that we know,” he said, adding, “There are other things at the site, at the scene, that indicate there was a—she did not leave on our own.”

In addition to concerns over Nancy’s medication, Sheriff Nanos—who emphasized in an earlier update that the octogenarian is of sound mind—expressed worry that she may have been exposed to the natural elements.

Savannah, meanwhile, was absent from Today earlier that morning, though the 54-year-old—who has two siblings, Annie Guthrie and Camron Guthrie—did share some words with the morning show.

"On behalf of our family, I want to thank everyone for the thoughts, prayers and messages of support," she said in her statement. "Right now, our focus remains on the safe return of our dear Nancy."

"We thank law enforcement for their hard work on this case," Savannah added, "and encourage anyone with information to contact the Pima County Sheriff's Department."

Following the news of Nancy’s disappearance, Savannah’s Today family, including Jenna Bush Hager and Sheinelle Jones, shared their support.

“We love Nancy, I know her personally,” Jenna said Feb. 2 on Today with Jenna & Sheinelle, during which she reiterated how vital it is that Nancy gets her medicine soon. “We are thinking of our dearest, dearest Savannah and her whole family right now. Our prayers obviously go out to Savannah and the entire family.”

For a closer look at Savannah’s bond with her mom—who the TV anchor has previously described as a “consistent doer of the right thing”—and her other loved ones, read on.